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Before initiating therapy of fibrocystic breast disease with Danazolcarcinoma of the breast should be excludedHowevernodularitypaintenderness due to fibrocystic breast disease may prevent recognition of underlying carcinoma before treatment is begunThereforeif any nodule persists or enlarges during treatmentcarcinoma should be considered and ruled out.

Rasheswhich may be maculopapularpetechialor purpuric or may take an urticarial form and may be accompanied by facial oedemaAssociated fever has also been reportedRarelysun-sensitive rash has been notedInflammatory erythematous noduleschanges in skin pigmentationexfoliative dermatitis and erythema multiforme have also been reported.

Danazol is indicated for the treatment of endometriosis amenable to hormonal management.

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Induction of aminolevulinic acidALAsynthetaseand reduction in thyroid binding globulinT4with increased uptake of T3 but without disturbance of thyroid stimulating hormone or free thyroxin indexis also likely during therapy.

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