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It may be harder to control your blood sugar when your body is stressedsuch as due to feverinfectioninjuryor surgeryConsult your doctor because this may require a change in your treatment planmedicationsor blood sugar testing.
Sulfonylurea drugs are extensively bound to serum proteinsDisplacement from protein binding sites by other drugs may lead to enhanced hypoglycemic actionIn vitrothe protein binding exhibited by glyburide is predominantly non-ionicwhereas that of other sulfonylureaschlorpropamidetolbutamidetolazamideis predominantly ionicAcidic drugs such as phenylbutazonewarfarinand salicylates displace the ionic-binding sulfonylureas from serum proteins to a far greater extent than the non-ionic binding glyburideIt has not been shown that this difference in protein binding will result in fewer drug-drug interactions with MICRONASE Tablets in clinical use.
You are allergic to any ingredient in Micronase you have type 1 diabetes or certain severe problems associated with diabetesegdiabetic ketoacidosisdiabetic comayou have moderate to severe burns or very high blood acid levelsacidosisyou are pregnant and are within 2 weeks of the expected delivery date you are taking bosentan.
All sulfonylureas including MICRONASE are capable of producing severe hypoglycemiaProper patient selection and dosage and instructions are important to avoid hypoglycemic episodesRenal or hepatic insufficiency may cause elevated drug levels of glyburide and the latter may also diminish gluconeogenic capacityboth of which increase the risk of serious hypoglycemic reactionsElderlydebilitated or malnourished patientsand those with adrenal or pituitary insufficiencyare particularly susceptible to the hypoglycemic action of glucoselowering drugsHypoglycemia may be difficult to recognize in the elderly and in people who are taking betaadrenergic blocking drugsHypoglycemia is more likely to occur when caloric intake is deficientafter severe or prolonged exercisewhen alcohol is ingestedor when more than one glucose lowering drug is usedThe risk of hypoglycemia may be increased with combination therapy.
In a single-dose interaction study in NIDDM subjectsdecreases in glyburide AUC and Cmax were observedbut were highly variableThe single-dose nature of this study and the lack of correlation between glyburide blood levels and pharmacodynamic effectsmakes the clinical significance of this interaction uncertainCoadministration of glyburide and metformin did not result in any changes in either metformin pharmacokinetics or pharmacodynamics.
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