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If serum potassium increases during aldactone administration but drops when aldactone is discontinued, a presumptive diagnosis of primary hyperaldosteronism should be considered.

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Tat hypkalmia with IV glucos (dxtos 25% in wat), concuntly with apid-acting insulin and IV sodium bicabonat; oal/ctal solutions Kayxalat in sobitol can b usd i ndd.

Jay W. Maks, MD, is a boad-ctiid intnist and gastontologist. H gaduatd om Yal Univsity School Mdicin and taind in intnal mdicin and gastontology at UCLA/Cdas-Sinai Mdical Cnt in Los Angls.

Dans ls dux cas, ls doss sont adapts a la pons diutiqu t au bilan lctolytiqu du malad.

Coadministation PO suspnsion and lithium ducs th nal claanc lithium, inducing a high isk lithium toxicity potd that coadministation PO suspnsion and an NSAID can duc th diutic, natiutic, and antihyptnsiv ct loop, potassium-spaing, and thiazid diutics NSAID administation can duc diutic, natiutic, and antihyptnsiv ct diutics; whn spionolacton and NSAIDs a usd concomitantly, monitclosly tdtmin i th dsid ct th diutic is obtaind Actylsalicylic acid may duc th icacy spionolacton; coadministation with actylsalicylic acid may nd tb titatd thigh maintnanc dos and monitclosly tdtmin i th dsid ct is obtaind Coadministation spionolacton with potassium supplmntation, salt substituts containing potassium, a dit ich in potassium, dugs that can incas potassium (g, AC inhibitos, ABs, NSAIDs, hpain and low molcula wight hpain) may lad tsv hypkalmia isk wosning nal unction can alsoccu with concomitant us nphotoxic dugs (g, aminoglycosids, cisplatin, NSAIDs); monitvolum status and nal unction piodically Spionolacton and its mtabolits int with adioimmunoassays digoxin and incas th appant xposu tdigoxin; us an assay that dos not intact with spionolacton Hypkalmic mtabolic acidosis potd in patints givn spionolacton concuntly with cholstyamin.

L suivi ds patints, t notammnt ds patints a isqu, dva compot un ionogamm sanguin, avc n paticuli un contol d la kalimi, d la natmi, t d la onction nal:

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