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Coadministration with drugsegCYP inducerswhere significant decreases in nevirapine plasma concentrations may occurwhich may result in loss of virologic response and possible resistance and cross-resistance to other NNRTIs.

An increase in weight and in levels of blood lipids and glucose may occur during antiretroviral therapySuch changes may in part be linked to disease control and life styleFor lipidsthere is in some cases evidence for a treatment effectwhile for weight gain there is no strong evidence relating this to any particular treatmentFor monitoring of blood lipids and glucose reference is made to established HIV treatment guidelinesLipid disorders should be managed as clinically appropriate.

Combination therapy with nevirapine is not a curative treatment of patients infected with HIV-1patients may continue to experience illnesses associated with advanced HIV-1 infectionincluding opportunistic infections.

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