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If you become pregnant while taking Synthroiddo not stop taking the medicine without your doctor’s adviceHaving low thyroid hormone levels during pregnancy could harm both mother and babyYour dose needs may be different during pregnancy.

Circulating thyroid hormones are greater than 99bound to plasma proteinsincluding thyroxinebinding globulinTBGthyroxine-binding prealbuminTBPAand albuminTBAwhose capacities and affinities vary for each hormoneThe higher affinity of both TBG and TBPA for T 4 partially explains the higher serum levelsslower metabolic clearanceand longer half-life of T 4 compared to T 3Protein-bound thyroid hormones exist in reverse equilibrium with small amounts of free hormoneOnly unbound hormone is metabolically activeMany drugs and physiologic conditions affect the binding of thyroid hormones to serum proteinssee DRUG INTERACTIONS and Drug-Laboratory Test InteractionsThyroid hormones do not readily cross the placental barriersee PRECAUTIONSPregnancy

Frequency not reportedTremorsmuscle weaknessmuscle crampsincreased risk of osteoporosisRef]

The adequacy of therapy is determined by periodic assessment of appropriate laboratory tests and clinical evaluationThe choice of laboratory tests depends on various factors including the etiology of the underlying thyroid diseasethe presence of concomitant medical conditionsincluding pregnancyand the use of concomitant medicationssee DRUG INTERACTIONS and DrugLaboratory Test InteractionsPersistent clinical and laboratory evidence of hypothyroidism despite an apparent adequate replacement dose of SYNTHROID may be evidence of inadequate absorptionpoor compliancedrug interactionsor decreased T 4 potency of the drug product.

Check with your doctor immediately if any of the following side effects occur while taking levothyroxine:

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during both of my pregnancies, my doctor took me off synthroid.