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Perforation of the gastrointestinal tractPrednisone can cause holes in the stomach or intestinal liningTell your doctor if you have a history of ulcers or other digestive system problems.

Once control has been establishedtwo courses are availableachange to ADT and then gradually reduce the amount of corticoid given every other day orbfollowing control of the disease process reduce the daily dose of corticoid to the lowest effective level as rapidly as possible and then change over to an alternate day scheduleTheoreticallycourseamay be preferable.

ADT is a corticosteroid dosing regimen in which twice the usual daily dose of corticoid is administered every other morningThe purpose of this mode of therapy is to provide the patient requiring long-term pharmacologic dose treatment with the beneficial effects of corticoids while minimizing certain undesirable effectsincluding pituitary-adrenal suppressionthe Cushingoid statecorticoid withdrawal symptomsand growth suppression in children.

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