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All patients starting therapy with VYTORIN or whose dose of VYTORIN is being increased should be advised of the risk of myopathyincluding rhabdomyolysisand told to report promptly any unexplained muscle paintenderness or weakness particularly if accompanied by malaise or fever or if muscle signs and symptoms persist after discontinuing VYTORINVYTORIN therapy should be discontinued immediately if myopathyis diagnosed or suspectedIn most casesmuscle symptoms and CK increases resolved when simvastatin treatment was promptly discontinuedPeriodic CK determinations may be considered in patients starting therapy with VYTORIN or whose dose is being increasedbut there is no assurance that such monitoring will prevent myopathy.

Make sure any doctor caring for you knows you that you use Vytorinespecially if you have an infectioninjury or surgery.

Vytorin contains a combination of ezetimibe and simvastatinEzetimibe reduces the amount of cholesterol absorbed by the body.

The following drugs should not be used while you are taking Vytorinboceprevircyclosporinedanazolgemfibrozilnefazodonetelaprevircertain antibioticsclarithromycinerythromycintelithromycinantifungal medicationitraconazoleketoconazoleposaconazolevoriconazoleor certain HIV/AIDS medicationatazanavircobicistatStribildTybostindinavirnelfinavirritonavirsaquinavirtipranavir

Ezetimibe is a whitecrystalline powder that is freely to very soluble in ethanolmethanoland acetone and practically insoluble in waterIts structural formula is:

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