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Sirna screening of several gpcrs and their ligands revealed that the depletion of cxcr1 and its ligand cxcl8 inhibit immunogenic translocation of calreticulin to the cell surface in the methotrexate treated cancer cells.

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When this medication is used with radiation treatmentit may rarely increase the risk of tissue and bone damageDiscuss the risks and benefits of your treatment with your doctor.

Methotrexate has caused birth defects and death in unborn babiesWomen must avoid becoming pregnant while taking this medicationPregnant women who have psoriasis or rheumatoid arthritis must not use methotrexateSee also Precautions section

Methotrexate is usually taken as a single weekly dose on the same day every weekThe recommended dose may be taken all at once or it may be divided into equal separate doses taken on the same day every weekif necessary.

Read the Patient Information Leaflet if available from your pharmacist before you start taking methotrexate and each time you get a refillIf you have any questionsask your doctor or pharmacist.

If you are a manuse a condom to keep from causing a pregnancy while you are using methotrexateContinue using condoms for at least 3 months after your last dose.

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i have been on methotrexate for 7 years first 6 yrs was oral tablets and the last year has been injectable and have had several side effects but it has controlled the ra and i benefit from taking it with pretty decent mobility and not a lot of pain.