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Patients with hepatic insufficiency due to cirrhosisIn these patientsthe dosage of CRIXIVAN should be lowered because of decreased metabolism of CRIXIVANsee DOSAGE AND ADMINISTRATIONPatients with renal insufficiencyPatients with renal insufficiency have not been studied.

Acute hemolytic anemiaincluding cases resulting in deathhas been reported in patients treated with CRIXIVANOnce a diagnosis is apparentappropriate measures for the treatment of hemolytic anemia should be institutedincluding discontinuation of CRIXIVAN.

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