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Read the Medication Guide if available from your pharmacist before you start taking hydroxyurea and each time you get a refillIf you have any questionsask your doctor or pharmacist.

Three mechanisms of action have been postulated for the increased effectiveness of concomitant use of hydroxyurea therapy with irradiation on squamous cellepidermoidcarcinomas of the head and neckIn vitro studies utilizing Chinese hamster cells suggest that hydroxyurea1is lethal to normally radioresistant S-stage cellsand2holds other cells of the cell cycle in the G1 or pre-DNA synthesis stage where they are most susceptible to the effects of irradiationThe third mechanism of action has been theorized on the basis of in vitro studies of HeLa cellsIt appears that hydroxyureaby inhibition of DNA synthesishinders the normal repair process of cells damaged but not killed by irradiationthereby decreasing their survival rateRNA and protein syntheses have shown no alteration.

For treating cancerDose should be titrated based on individual patient responseCapsules should be swallowed wholeHydroxyurea capsules should be handled with extreme care and disposed of properly because it causes cell damage.

It is important to make sure you are taking the correct amount of medication every timeBefore every dosecheck that what you are taking matches what you have been prescribed.

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